Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | CD13 expression is regulated by differentiation agents, such as phorbol esters, transforming growth factor-beta, interleukin-4 and interleukin-10 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',3-dinitroflavone-8-acetic acid | - |
Homo sapiens | |
actinonin | - |
Homo sapiens | |
adhesion/signaling-inducing antibody 452 | - |
Homo sapiens | |
amastatin | - |
Homo sapiens | |
anti-CD13 monoclonl antibody WM15 | - |
Homo sapiens | |
bestatin | ubenimex | Homo sapiens | |
betulinic acid | - |
Homo sapiens | |
bradykinin | bradykinin is resistant to hydrolysis by CD13, acting rather as a natural inhibitor | Homo sapiens | |
coronavirus infection inhibitor Y2-K | - |
Homo sapiens | |
curcumin | - |
Homo sapiens | |
ezetimibe | - |
Homo sapiens | |
icatibant | - |
Homo sapiens | |
leuhistin | - |
Homo sapiens | |
LVV-hemorphin-7 | - |
Homo sapiens | |
additional information | the neuropeptide substance P inhibits enkephalin cleavage by CD13 | Homo sapiens | |
phebestin | - |
Homo sapiens | |
probestin | - |
Homo sapiens | |
puromycin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
160000 | - |
about 160000 Da | Homo sapiens |
260000 | - |
the protein present in sera of patients with cholestatic diseases is later found to be a high molecular isoform of CD13 (260 kDa) | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | where initial removal of the NH2-terminal dipeptide from CXCL11 by CD26 allows for further truncation by CD13 | ? | - |
? | |
additional information | Homo sapiens | aminopeptidase N removes N-terminal amino acids from unsubstituted oligopeptides, amide or arylamide, with the exception of peptides with Pro in the penultimate position, the order of favored substrates is Ala>Phe>Tyr>Leu>Arg>Thr>Trp>Lys> Ser>Asp>His>Val | ? | - |
? | |
additional information | Homo sapiens | CD13 degrades the chemokine CXCL11, downregulates CXCR4 and modulates stromal cell-derived factor-1 (also known as CXCL12)-induced migration | ? | - |
? | |
additional information | Homo sapiens | CD13 hydrolyzes synthetic oligopeptides corresponding to the N terminus of interleukin-1a, interleukin-1b and interleukin-2, although natural interleukin-2 and G-CSF are resistant to hydrolysis | ? | - |
? | |
additional information | Homo sapiens | CD13 is a receptor for human coronavirus 229E and human cytomegalovirus | ? | - |
? | |
additional information | Homo sapiens | in vitro, CD13 participates in the metabolism of glutathione, somatostatin, thymopentin, neurokinin A, splenopentin, nociceptin (orphanin) FQ, and peptides derived from the thrombin receptor | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
acute myeloid leukemia cell | - |
Homo sapiens | - |
alveolar macrophage | - |
Homo sapiens | - |
bile | - |
Homo sapiens | - |
CL1-0 cell | - |
Homo sapiens | - |
dendritic cell | - |
Homo sapiens | - |
endothelial cell | - |
Homo sapiens | - |
intestinal epithelium | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lymphocyte | - |
Homo sapiens | - |
monocyte | - |
Homo sapiens | - |
nervous system | - |
Homo sapiens | - |
pericyte | - |
Homo sapiens | - |
renal epithelium | - |
Homo sapiens | - |
serum | - |
Homo sapiens | - |
spermatid | - |
Homo sapiens | - |
synoviocyte | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin III + H2O | - |
Homo sapiens | angiotensin IV + L-Arg | - |
? | |
entactin + H2O | - |
Homo sapiens | ? | - |
? | |
L-Ala-p-nitroanilide + H2O | - |
Homo sapiens | L-Ala + p-nitroaniline | - |
? | |
Leu-enkephalin-L-Tyr-Gly + H2O | - |
Homo sapiens | Leu + enkephalin-L-Tyr-Gly | - |
? | |
Lys-des-Arg9-bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
lysyl-bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
Met-enkephalin-L-Tyr-Gly + H2O | - |
Homo sapiens | Met + enkephalin L-Tyr-Gly | - |
? | |
additional information | where initial removal of the NH2-terminal dipeptide from CXCL11 by CD26 allows for further truncation by CD13 | Homo sapiens | ? | - |
? | |
additional information | aminopeptidase N removes N-terminal amino acids from unsubstituted oligopeptides, amide or arylamide, with the exception of peptides with Pro in the penultimate position, the order of favored substrates is Ala>Phe>Tyr>Leu>Arg>Thr>Trp>Lys> Ser>Asp>His>Val | Homo sapiens | ? | - |
? | |
additional information | CD13 degrades the chemokine CXCL11, downregulates CXCR4 and modulates stromal cell-derived factor-1 (also known as CXCL12)-induced migration | Homo sapiens | ? | - |
? | |
additional information | CD13 hydrolyzes synthetic oligopeptides corresponding to the N terminus of interleukin-1a, interleukin-1b and interleukin-2, although natural interleukin-2 and G-CSF are resistant to hydrolysis | Homo sapiens | ? | - |
? | |
additional information | CD13 is a receptor for human coronavirus 229E and human cytomegalovirus | Homo sapiens | ? | - |
? | |
additional information | in vitro, CD13 participates in the metabolism of glutathione, somatostatin, thymopentin, neurokinin A, splenopentin, nociceptin (orphanin) FQ, and peptides derived from the thrombin receptor | Homo sapiens | ? | - |
? | |
tuftsin + H2O | the first peptidic bond of this tuftsin is hydrolyzed by CD13, generating an antagonist that competes for receptor binding and thus regulating tuftsin functions | Homo sapiens | ? | - |
? | |
Type IV collagen + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | x-ray crystallography | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase N | the enzyme is named aminopeptidase N because of its preference for neutral amino acids | Homo sapiens |
APN | - |
Homo sapiens |
CD13 | - |
Homo sapiens |